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NALCN antibody (Sodium Leak Channel, Non-Selective) (AA 1659-1738) (APC) Primary Antibody

NALCN Reactivity: Human, Mouse, Rat ICC, IF, WB Host: Mouse Monoclonal S187-7 APC
Catalog No. ABIN2483028
$535.60
Plus shipping costs $45.00
100 μg
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  • Target
    NALCN
    Binding Specificity
    • 10
    • 4
    • 2
    AA 1659-1738
    Reactivity
    • 16
    • 12
    • 12
    • 1
    Human, Mouse, Rat
    Host
    • 12
    • 7
    Mouse
    Clonality
    • 12
    • 7
    Monoclonal
    Conjugate
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NALCN antibody is conjugated to APC
    Application
    • 14
    • 10
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    Detects ~200 kDa.
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
    Clone
    S187-7
    Isotype
    IgG1
  • Application Notes
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2483028 was sufficient for detection of NALCN in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    NALCN
    Alternative Name
    NALCN (NALCN Antibody Abstract)
    Synonyms
    VGCNL1, zgc:113349, CanIon, bA430M15.1, A530023G15Rik, AI849508, Vgcnl1, sodium leak channel, non-selective, NALCN, nalcn, Nalcn
    Background
    NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
    Gene ID
    266760
    NCBI Accession
    NP_705894
    UniProt
    Q6Q760
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