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CHMP2A antibody (AA 1-100) (HRP)

This Rabbit Polyclonal antibody specifically detects CHMP2A in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Rat.
Catalog No. ABIN2559698

Quick Overview for CHMP2A antibody (AA 1-100) (HRP) (ABIN2559698)

Target

See all CHMP2A Antibodies
CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Reactivity

  • 27
  • 20
  • 6
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Rat

Host

  • 39
  • 2
Rabbit

Clonality

  • 41
Polyclonal

Conjugate

  • 12
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CHMP2A antibody is conjugated to HRP

Application

  • 32
  • 15
  • 13
  • 13
  • 10
  • 5
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 14
    • 8
    • 2
    • 2
    • 1
    • 1
    AA 1-100

    Cross-Reactivity

    Rat

    Predicted Reactivity

    Human,Mouse,Dog,Sheep

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human CHMP2A

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

    Alternative Name

    CHMP2A

    Background

    Synonyms: BC2, BC-2, VPS2, CHMP2, VPS2A, Charged multivesicular body protein 2a, Chromatin-modifying protein 2a, CHMP2a, Putative breast adenocarcinoma marker BC-2, Vacuolar protein sorting-associated protein 2-1, Vps2-1, hVps2-1

    Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

    Gene ID

    27243

    UniProt

    O43633

    Pathways

    SARS-CoV-2 Protein Interactome
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