ICOS antibody (PE-Cy7)

Catalog No. ABIN2567413

The PE-Cy7-conjugated Mouse Monoclonal anti-ICOS antibody (Clone ISA-3) (ABIN2567413) specifically detects ICOS in FACS. The antibody is reactive with Human samples.

Quick Overview for ICOS antibody (PE-Cy7) (ABIN2567413)

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICOS antibody is conjugated to PE-Cy7

Application: Flow Cytometry (FACS)

Clone: ISA-3

Product Details anti-ICOS Antibody (PE-Cy7)

Specificity: The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1.

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Storage: 4 °C

Storage Comment: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Target Details for ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Alternative Name: CD278

Background: The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4,5,10 in T cells.

Gene ID: 29851

UniProt: Q9Y6W8

Pathways: Cancer Immune Checkpoints