KLRB1B antibody
KLRB1B
Reactivity: Mouse
FACS, IP, WB
Host: Mouse
Monoclonal
1C10
unconjugated
-
- Target See all KLRB1B products
- KLRB1B (Killer Cell Lectin-Like Receptor Subfamily B Member 1B (KLRB1B))
- Reactivity
- Mouse
- Host
- Mouse
- Clonality
- Monoclonal
- Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
- Characteristics
- Synonyms: NKRP1, Klrb1c NKR-P1
- Purification
- Purified
- Immunogen
- Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c XC57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cell line.
- Clone
- 1C10
- Isotype
- IgG
-
- Application Notes
-
Western Blot (1-5 μg/mL). Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
-
- Buffer
- PBS containing 0.08 % Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
-
Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. - Expiry Date
- 12 months
-
- Target
- KLRB1B (Killer Cell Lectin-Like Receptor Subfamily B Member 1B (KLRB1B))
- Alternative Name
- Natural Killer Cell Receptor-P1 (KLRB1B Products)
- Synonyms
- Klrb1d antibody, Ly55b antibody, Ly55d antibody, NKR-P1B antibody, NKR-P1D antibody, Nkrp1-b antibody, Nkrp1d antibody, Nkr-p1b antibody, Nkrp1b antibody, killer cell lectin-like receptor subfamily B member 1B antibody, Klrb1b antibody
- Background
- Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10 % of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. An activation signal is known to exist, however the mechanics of this signal are not very well understood.Synonyms: Klrb1c NKR-P1, NKRP1
- UniProt
- Q61970
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