SMC2 antibody (AA 523-768)

Catalog No. ABIN264446

The Mouse Monoclonal anti-SMC2 antibody is suitable to detect SMC2 in samples from Human. It has been validated for WB.

Quick Overview for SMC2 antibody (AA 523-768) (ABIN264446)

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SMC2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: E1M

Product Details anti-SMC2 Antibody

Binding Specificity: AA 523-768

Specificity: Recognizes SMC2/CAPE.

Characteristics: Synonyms: SMC protein 2, SMC-2, SMC2L1, CAP-E, Chromosome-associated protein E, XCAP-Ehomolog, Structural maintenance of chromosomes protein 2

Purification: Purified

Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinantprotein corresponding to amino acids 523-768 of Human CAP-E and Mouse myeloma cells. Genename: SMC2

Isotype: IgG

Application Details

Application Notes: Western Blot: 1-5 μg/mL. Positive Control/Tissue Expression: HeLa cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.08 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for SMC2

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Alternative Name: SMC2 / CAPE

Background: CAP-E and CAP-C (Chromosome Associated Protein-E & C) are also SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation to achieve proper segregation of genetic information during subsequent cell division. hCAP-C/hCAP-E is a component of a multiprotein complex called condensin that interacts with phosphorylation of Histone H3 resulting in the mitotic chromosome condensation. The distribution patterns of the two heterodimeric complexes in interphase nucleus indicate independent behaviour of the two complexes during cell cycle. These results suggest that the two distinct complexes are involved in different aspects of mitotic chromosome organization in human cells.Synonyms: CAP-E, Chromosome-associated protein E, SMC protein 2, SMC-2, SMC2L1, Structural maintenance of chromosomes protein 2, XCAP-E homolog

Gene ID: 10592

UniProt: O95347