GABBR2 antibody

Catalog No. ABIN264843

This anti-GABBR2 antibody is a Rabbit Polyclonal antibody detecting GABBR2 in WB and IF. Suitable for Human, Rat and Mouse.

Quick Overview for GABBR2 antibody (ABIN264843)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABBR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-GABBR2 Antibody

Specificity: The antibody recognizes C-terminal of Gamma-Aminobutyric Acid (GABA) B Receptor 2 (recognized epitope: the last 23 aa). GB2 Apparent MW: ~120 kDa.

Cross-Reactivity (Details): Species reactivity (expected):Human.
Species reactivity (tested):Mouse, Rat.

Purification: Affinity Chromatography on Protein G

Immunogen: Synthetic peptide (coupled with THG) derived from the last 23 aa of Mouse GABA B receptor 2.

Application Details

Application Notes: Western blot: 0.6 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.4, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Alternative Name: GABBR2

Background: GABA B receptor is a G-protein-coupled inhibitory receptor of g-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains. The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit contains the determinants required for G-protein signaling. Multiple allosteric interactions between the two subunits are required for correct functioning of the receptor. There are two N-terminal splice variants of GB1 subunit, termed GB1a and GB1b, their expression in the central nervous system changes during the ontogenesis and differs between various regions of the brain.Synonyms: G-protein coupled receptor 51, GABA-B receptor 2, GABA-B-R2, GABBR-2, GPR51, GPRC3B, Gamma-aminobutyric acid type B receptor subunit 2, Gb2, HG20

Gene ID: 9568

NCBI Accession: NP_005449

UniProt: O75899

Pathways: cAMP Metabolic Process