EBV antibody

Catalog No. ABIN264912

Product Details anti-EBV Antibody

Target: EBV (Epstein-Barr Virus (EBV))

Reactivity: Epstein-Barr Virus (EBV)

Host: Sheep

Clonality: Polyclonal

Conjugate: This EBV antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Isotype: IgG

Application Details

Application Notes: Western Blot: 0.25-1.00 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS, 0.08 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

References for anti-EBV antibody (ABIN264912)

Anderton, Yee, Smith, Crook, White, Allday: "Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma." in: Oncogene, Vol. 27, Issue 4, pp. 421-33, (2008) (PubMed).

Jiménez-Ramírez, Brooks, Forshell, Yakimchuk, Zhao, Fulgham, Sample: "Epstein-Barr virus EBNA-3C is targeted to and regulates expression from the bidirectional LMP-1/2B promoter." in: Journal of virology, Vol. 80, Issue 22, pp. 11200-8, (2006) (PubMed).

Yuan, Cahir-McFarland, Zhao, Kieff: "Virus and cell RNAs expressed during Epstein-Barr virus replication." in: Journal of virology, Vol. 80, Issue 5, pp. 2548-65, (2006) (PubMed).

Hong, Gulley, Feng, Delecluse, Holley-Guthrie, Kenney: "Epstein-Barr virus lytic infection contributes to lymphoproliferative disease in a SCID mouse model." in: Journal of virology, Vol. 79, Issue 22, pp. 13993-4003, (2005) (PubMed).

Maruo, Johannsen, Illanes, Cooper, Kieff: "Epstein-Barr Virus nuclear protein EBNA3A is critical for maintaining lymphoblastoid cell line growth." in: Journal of virology, Vol. 77, Issue 19, pp. 10437-47, (2003) (PubMed).

Rosendorff, Illanes, David, Lin, Kieff, Johannsen: "EBNA3C coactivation with EBNA2 requires a SUMO homology domain." in: Journal of virology, Vol. 78, Issue 1, pp. 367-77, (2003) (PubMed).

ONions, Allday: "Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2." in: Oncogene, Vol. 22, Issue 46, pp. 7181-91, (2003) (PubMed).

Target Details for EBV

Target: EBV (Epstein-Barr Virus (EBV))

Alternative Name: Epstein Barr Virus / EBV (EBV Products)

Target Type: Virus

Background: EBNA-3A is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA-3A functions as a transcriptional regulator though the target genes are currently unknown. Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.Synonyms: HHV-4, HHV4

Molecular Weight: 102.4 kDa