EPH Receptor B1 antibody

Catalog No. ABIN264959

The Sheep Polyclonal anti-EPH Receptor B1 antibody has been validated for IP. It is suitable to detect EPH Receptor B1 in samples from Human.

Quick Overview for EPH Receptor B1 antibody (ABIN264959)

Target: EPH Receptor B1 (EPHB1)

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This EPH Receptor B1 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-EPH Receptor B1 Antibody

Specificity: This antibody reacts to ephB1 (Elk receptor) - EXT.

Purification: Purified

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 - 10 μg/mL. Immunoprecipitation: 10 - 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for EPH Receptor B1

Target: EPH Receptor B1 (EPHB1)

Alternative Name: EPHB1

Background: The immunogen used for the anti-human ephB1 (Elk receptor) -EXT region was a GST fusion protein ephB1 (Elk receptor) -EXT corresponding to amino acid sequence 16-351 of the N terminus region and having a molecular weight of 116 kD. ephB1, previously known as Elk(eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.Synonyms: ELK, EPH2, EPHT2, Ephrin type-B receptor 1, HEK6, NET, Tyrosine-protein kinase receptor EPH-2

Gene ID: 2047

NCBI Accession: NP_004432

UniProt: P54762

Pathways: RTK Signaling