EPH Receptor B1 antibody (C-Term)

Catalog No. ABIN391917

Product Details anti-EPH Receptor B1 Antibody

Target: EPH Receptor B1 (EPHB1)

Binding Specificity: AA 955-984, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 955-984 amino acids from the C-terminal region of human EphB1.

Clone: RB1648

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-EPH Receptor B1 antibody (ABIN391917)

Sheng, Wang, Dong, Ma, Zhou, Sugimura, Lu, Zhou: "EphB1 is underexpressed in poorly differentiated colorectal cancers." in: Pathobiology : journal of immunopathology, molecular and cellular biology, Vol. 75, Issue 5, pp. 274-80, (2008) (PubMed).

Wang, Dong, Sheng, Ma, Li, Wang, Lu, Sugimura, Jin, Zhou: "Loss of expression of EphB1 protein in gastric carcinoma associated with invasion and metastasis." in: Oncology, Vol. 73, Issue 3-4, pp. 238-45, (2008) (PubMed).

Target Details for EPH Receptor B1

Target: EPH Receptor B1 (EPHB1)

Alternative Name: EphB1 (EPHB1 Products)

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Molecular Weight: 109885

Gene ID: 2047

NCBI Accession: NP_004432

UniProt: P54762

Pathways: RTK Signaling