RED1 antibody (AA 6-66)

Catalog No. ABIN264972

Cited in 2+ publications. The Sheep Polyclonal anti-RED1 antibody (ABIN264972) specifically detects RED1 in WB and IF. The antibody is reactive with Rat samples.

Quick Overview for RED1 antibody (AA 6-66) (ABIN264972)

Target: RED1 (ADARB1) (Adenosine Deaminase, RNA-Specific, B1 (ADARB1))

Reactivity: Rat

Host: Sheep

Clonality: Polyclonal

Conjugate: This RED1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RED1 Antibody

Binding Specificity: AA 6-66

Specificity: This antibody recognizes ADAR2 (Adenosine Deaminase Acting on RNA 2).

Purification: Purified

Immunogen: GST fusion protein containing aa 6-66 of the rat RED1 coding sequence

Isotype: IgG

Application Details

Application Notes: Western Blot: 1: 1000. POSITIVE CONTROL: Rat Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

References for anti-RED1 antibody (ABIN264972)

Yamashita, Chai, Teramoto, Tsuji, Shimazaki, Muramatsu, Kwak: "Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons." in: EMBO molecular medicine, Vol. 5, Issue 11, pp. 1710-9, (2013) (PubMed).

Dorsam, Graeler, Seroogy, Kong, Voice, Goetzl: "Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 7, pp. 3500-7, (2003) (PubMed).

Target Details for RED1

Target: RED1 (ADARB1) (Adenosine Deaminase, RNA-Specific, B1 (ADARB1))

Alternative Name: ADARB1 / ADAR2

Background: RED 1 also called ADAR2 is involved in the editing of the messenger RNAs for glutamate receptor (GluR) subunits by siteselective adenosine deamination. It edits both the GluR-B Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently.Synonyms: DRADA2, Double-stranded RNA-specific editase 1, RED1, RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase

Molecular Weight: 80.7 kDa

Gene ID: 25367

NCBI Accession: NP_001104525

UniProt: P51400