S1PR5 antibody (C-Term)

Catalog No. ABIN264983

The Rabbit Polyclonal anti-S1PR5 antibody is suitable to detect S1PR5 in samples from Human. It has been validated for WB.

Quick Overview for S1PR5 antibody (C-Term) (ABIN264983)

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-S1PR5 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to EDG8.

Purification: Purified

Immunogen: Unique synthetic peptide derived from the C-terminus of the human EDG-8 protein

Isotype: IgG

Application Details

Application Notes: Western Blot: 5 - 10 μg/mL, detects recombinant EDG-8 receptors at 42 kDa, Due to lowexpression of EDG receptors, we recommend use of Pierce Femto Signal substrate forwestern blot development.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for S1PR5

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Alternative Name: EDG-8 / S1P5

Background: Endothelial Cell Differentiation Gene-8 (EDG-8) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-8 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-8 is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.Synonyms: EDG8, Endothelial differentiation G-protein-coupled receptor 8, S1P receptor 5, S1PR5, SPPR-1, SPPR-2

Gene ID: 53637

NCBI Accession: NP_001159687

UniProt: Q9H228