S1PR4 antibody

Catalog No. ABIN265060

This Rabbit Polyclonal antibody specifically detects S1PR4 in WB. It exhibits reactivity toward Human.

Quick Overview for S1PR4 antibody (ABIN265060)

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-S1PR4 Antibody

Specificity: This antibody reacts to EDG-6 / S1P4 / S1PR4.

Purification: Purified

Immunogen: Synthetic peptide derived from the intermediate region of the EDG6 (S1P4) protein.

Isotype: IgG

Application Details

Application Notes: Western Blot: 5 - 10 μg/mL, Detects an approximately 42 kDa band on RH7777 cellstransfected with full-length EDG-6. Due to low expression of EDG receptors, we recommenduse of Pierce Femto Signal substrate for western blot development.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for S1PR4

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Alternative Name: S1PR4 / EDG6

Background: EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine 1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.Synonyms: EDG-6, Endothelial differentiation G-protein coupled receptor 6, S1P receptor Edg-6, Sphingosine 1-phosphate receptor 4, Sphingosine 1-phosphate receptor Edg-6

Gene ID: 8698

NCBI Accession: NP_003766

UniProt: O95977