IRF7 antibody (Middle Region)

Catalog No. ABIN265130

The Rabbit Polyclonal anti-IRF7 antibody has been validated for WB. It is suitable to detect IRF7 in samples from Human.

Quick Overview for IRF7 antibody (Middle Region) (ABIN265130)

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF7 Antibody

Binding Specificity: Middle Region

Specificity: This antibody reacts to Interferon regulatory factor 7 (IRF7).

Purification: Purified

Immunogen: Rabbit polyclonal IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF7

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 - 2 μg/mL. Expressed predominantly in spleen, thymus and peripheral blood leukocytes, IRF7 islocated in the nucleus and cytoplasm. The phosphorylated and active form accumulatesselectivly in the nucleus.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for IRF7

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Alternative Name: IRF7

Background: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.Synonyms: IRF-7, Interferon regulatory factor 7

Gene ID: 3665

NCBI Accession: NP_001563

UniProt: Q92985

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy