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GUCY1B3 antibody

GUCY1B3 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN265451
  • Target See all GUCY1B3 Antibodies
    GUCY1B3 (Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3))
    Reactivity
    • 31
    • 12
    • 10
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 30
    • 1
    Rabbit
    Clonality
    • 29
    • 2
    Polyclonal
    Conjugate
    • 26
    • 1
    • 1
    • 1
    • 1
    • 1
    This GUCY1B3 antibody is un-conjugated
    Application
    • 28
    • 17
    • 12
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects endogenous levels of Guanylate Cyclase β1/3 protein. (region surrounding Val21)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Purity
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product GUCY1B3 Primary Antibody
  • Application Notes
    ELISA: 1: 5000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    DO NOT FREEZE!
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    GUCY1B3 (Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3))
    Alternative Name
    Guanylate Cyclase Soluble GUCY1B3 (GUCY1B3 Products)
    Synonyms
    GUCY1B3 antibody, AMGC1 antibody, AmsGC-beta1 antibody, AmsGCbeta1 antibody, GB20021 antibody, Gucy1b3 antibody, gucy1b3 antibody, GC-S-beta-1 antibody, GC-SB3 antibody, GUC1B3 antibody, GUCB3 antibody, GUCSB3 antibody, GUCY1B1 antibody, SGCB1 antibody, GCbeta1 antibody, Gucy1b1 antibody, SGC antibody, guanylate cyclase 1 soluble subunit beta antibody, guanylate cyclase 1, soluble, beta 3 antibody, guanylate cyclase, soluble, beta 1 antibody, guanylate cyclase 1, soluble, beta 3 S homeolog antibody, guanylate cyclase 1 soluble subunit beta 3 antibody, GUCY1B3 antibody, gucy1b3 antibody, Gycbeta1 antibody, gucy1b3.S antibody, Gucy1b3 antibody
    Background
    Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.Synonyms: GCS-beta-1, GCS-beta-3, GUC1B3, GUCSB3, GUCY1B1, Guanylate cyclase soluble subunit beta-1, Guanylate cyclase soluble subunit beta-3, Soluble guanylate cyclase small subunit, sGC beta
    Molecular Weight
    approx. 70 kDa
    Gene ID
    2983
    NCBI Accession
    NP_000848
    UniProt
    Q02153
    Pathways
    Transition Metal Ion Homeostasis
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