DLL1 antibody
Quick Overview for DLL1 antibody (ABIN2656778)
Target
See all DLL1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Characteristics
- The Notch receptors and their ligands are highly conserved from invertebrates to mammals. The Delta-like 1 (DLL1) is one of the four or five Notch ligands identified. The binding to Notch receptor results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus.This translocation triggers a series of signaling process. Delta-like 1 is reported to be essential for the maintenance of marginal zone B cells in normal mice, and engagement of Notch 1 by DLL1 promotes differentiation of B lymphocytes to antibody-secreting cells.
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Purification
- The antibody was purified by affinity chromatography.
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Isotype
- IgG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 0.5 mg/mL
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Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- Store undiluted between 2°C and 8°C. Do not freeze.
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- DLL1 (delta-Like 1 (DLL1))
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Alternative Name
- DLL1
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Pathways
- Notch Signaling, Stem Cell Maintenance
Target
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