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CCR5 antibody (Alexa Fluor 488)
CCR5
Reactivity: Human
FACS, IHC, IP, Dep, Act, CMCD
Host: Mouse
Monoclonal
J418F1
Alexa Fluor 488
Product Details anti-CCR5 Antibody (Alexa Fluor 488)
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Target
See all CCR5 Antibodies
CCR5
(Chemokine (C-C Motif) Receptor 5 (CCR5))
Reactivity
All reactivities for CCR5 antibodies
Human
Host
All hosts for CCR5 antibodies
Mouse
Clonality
All clonalities for CCR5 antibodies
Monoclonal
Conjugate
All conjugates for CCR5 antibodies
This CCR5 antibody is conjugated to Alexa Fluor 488
Application
All applications for CCR5 antibodies
Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Depletion (Dep), Activation (Act), Complement Mediated Cell Depletion (CMCD)
Purification
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Clone
J418F1
Isotype
IgG2b kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C
Target Details for CCR5
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Target
CCR5
(Chemokine (C-C Motif) Receptor 5 (CCR5))
Alternative Name
CD195 (CCR5 Products )
Synonyms
CC-CKR-5 antibody, CCCKR5 antibody, CCR-5 antibody, CD195 antibody, CKR-5 antibody, CKR5 antibody, CMKBR5 antibody, IDDM22 antibody, Ckr5 antibody, Cmkbr5 antibody, CCR1-L antibody, GPCR antibody, CCR5 antibody, AM4-7 antibody, C-C motif chemokine receptor 5 (gene/pseudogene) antibody, chemokine (C-C motif) receptor 5 antibody, C-C motif chemokine receptor 5 antibody, CCR5 antibody, Ccr5 antibody
Background
CD195, also known as CCR5, is a 45 kD G protein-coupled seven transmembrane CC-chemokine receptor. It binds to MIP-1α, MIP-1β, and RANTES and is expressed on a subset of T cells and monocytes. CD195 mediates an intracellular signal thought to induce cell differentiation and proliferation. CCR5 has also been shown to act as a co-receptor for R5 HIV-1 cell entry, modification of CCR5 by sulfation contributes to the efficiency of HIV-1 entry. Studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Pathways
Cellular Response to Molecule of Bacterial Origin , cAMP Metabolic Process , Regulation of Cell Size
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