BST2 antibody (Alexa Fluor 647)

Catalog No. ABIN2657750

The Alexa Fluor 647-conjugated Rat Monoclonal anti-BST2 antibody (Clone 129c1) (ABIN2657750) specifically detects BST2 in FACS and EM. The antibody is reactive with Mouse samples.

Quick Overview for BST2 antibody (Alexa Fluor 647) (ABIN2657750)

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This BST2 antibody is conjugated to Alexa Fluor 647

Application: Flow Cytometry (FACS), Electron Microscopy (EM)

Clone: 129c1

Product Details anti-BST2 Antibody (Alexa Fluor 647)

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Alternative Name: CD317

Background: CD317, known as BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, or PDCA-1, is type II transmembrane glycoprotein with a molecular mass of 29-33 kD. It is predominantly expressed on Type I IFN-producing cells (IPCs) in naive mice, but is up-regulated on most cell types following stimulation with type I IFNs and IFN-gamma. It is highly expressed on terminally differentiated normal plasmacytoid dendritic cells and some tumor cells, such as multiple myeloma, renal cell carcinoma, and melanoma cells. BST2 was recently identified as an IFN-induced cellular response factor that blocks release of HIV-1 and other retroviruses from infected cells. BST2 has been found to be the natural ligand of ILT7 in human model.

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response