IL-21 antibody (Alexa Fluor 647)

Catalog No. ABIN2657954

This anti-IL-21 antibody is a Mouse Monoclonal antibody detecting IL-21 in FACS. Suitable for Human.

Quick Overview for IL-21 antibody (Alexa Fluor 647) (ABIN2657954)

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-21 antibody is conjugated to Alexa Fluor 647

Application: Flow Cytometry (FACS)

Clone: 3A3-N2

Product Details anti-IL-21 Antibody (Alexa Fluor 647)

Cross-Reactivity: Rhesus Monkey

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Alternative Name: IL-21

Background: Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response