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LRRC32 antibody (APC)

LRRC32 Reactivity: Human BCA Host: Mouse Monoclonal 7B11 APC
Catalog No. ABIN2658317
  • Target See all LRRC32 Antibodies
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    Reactivity
    • 27
    • 10
    • 9
    • 1
    Human
    Host
    • 20
    • 13
    • 1
    • 1
    Mouse
    Clonality
    • 21
    • 14
    Monoclonal
    Conjugate
    • 19
    • 7
    • 4
    • 2
    • 2
    • 1
    This LRRC32 antibody is conjugated to APC
    Application
    • 17
    • 16
    • 14
    • 6
    • 4
    • 3
    • 2
    • 1
    Biochemical Assay (BCA)
    Purification
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Clone
    7B11
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product LRRC32 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    Alternative Name
    GARP (LRRC32 Products)
    Synonyms
    D11S833E antibody, GARP antibody, AI426318 antibody, D11S833Eh antibody, D7H11S833E antibody, EG434215 antibody, Garp antibody, leucine rich repeat containing 32 antibody, LRRC32 antibody, Lrrc32 antibody
    Background
    Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs (CD4+, CD25+, FoxP3+ cells) and serves as a receptor for latent TGF-β. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1, an autosomal recessive disease characterized by profound congenital sensorineural deafness, vestibular dysfunction, and progressive visual loss. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-β or to capture TGF-β from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs.
    Pathways
    Activated T Cell Proliferation
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