CD39 antibody (PE-Cy7)

Catalog No. ABIN2659258

The Rat Monoclonal anti-CD39 antibody is suitable to detect CD39 in samples from Mouse. It has been validated for IHC, IP, ICFC, ELISPOT (Capture), Neut and ELISA (Capture).

Quick Overview for CD39 antibody (PE-Cy7) (ABIN2659258)

Target: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD39 antibody is conjugated to PE-Cy7

Application: Immunohistochemistry (IHC), Immunoprecipitation (IP), Intracellular Flow Cytometry (ICFC), ELISpot (Capture) (ELISPOT (Capture)), Neutralization (Neut), ELISA (Capture)

Clone: Duha59

Product Details anti-CD39 Antibody (PE-Cy7)

Purification: The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD39

Target: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Alternative Name: CD39

Background: CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of the ectonucleoside triphosphate dihydrolases (E-NTPDases), which are involved in regulating extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system and is involved in suppression of inflammation and control of platelet activation. CD39 is expressed on B cells, dendritic cells, and a subset of T cells, including regulatory T cells and memory T cells. The coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops.