Fc epsilon RI/FCER1A antibody (PE-Cy7)

Catalog No. ABIN2659345

The Armenian Hamster Monoclonal anti-Fc epsilon RI/FCER1A antibody has been validated for FACS and CyTOF. It is suitable to detect Fc epsilon RI/FCER1A in samples from Mouse.

Quick Overview for Fc epsilon RI/FCER1A antibody (PE-Cy7) (ABIN2659345)

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Reactivity: Mouse

Host: Armenian Hamster

Clonality: Monoclonal

Conjugate: This Fc epsilon RI/FCER1A antibody is conjugated to PE-Cy7

Application: Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)

Clone: MAR-1

Product Details anti-Fc epsilon RI/FCER1A Antibody (PE-Cy7)

Purification: The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for Fc epsilon RI/FCER1A

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Alternative Name: Fc epsilon RI alpha

Background: FcεRIα is a transmembrane protein belonging to the Ig superfamily. FcεRIα forms a tetrameric complex with one β and two γ-subunits. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via Fcε RIα, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcεRIα subunit.

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process