CCRL2 antibody (PE)

Catalog No. ABIN2662410

Product Details anti-CCRL2 Antibody (PE)

Target: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCRL2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: K097F7

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CCRL2

Target: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Alternative Name: CCRL2 (CCRL2 Products)

Synonyms: CCRL2 antibody, ACKR5 antibody, CKRX antibody, CRAM antibody, CRAM-A antibody, CRAM-B antibody, HCR antibody, 1810047I05Rik antibody, Ackr5 antibody, CCR11 antibody, Cmkbr1l2 antibody, E01 antibody, L-CCR antibody, C-C motif chemokine receptor like 2 antibody, chemokine (C-C motif) receptor-like 2 antibody, Ccrl2 antibody, CCRL2 antibody

Background: CCRL2 (C-C chemokine receptor-like 2) is a seven transmembrane, G-protein coupled receptor with two isoforms generated from alternative splicing. CCRL2 is expressed by the majority of cell types of hematopoietic origin, including monocytes, macrophages, neutrophils, lymphocytes, and NK cells. In some cell types, its expression is upregulated by inflammatory stimuli. CCRL2 is important for the development of Th2 responses and may act as a decoy receptor capturing and endocyting its ligands CCL5 and CCL19, however, it has been found that CCRL2 captures and retains chemerin/RARRES2 on its cell surface, presenting it to neighboring cells.