FZD4 antibody (PE)

Catalog No. ABIN2663398

The Mouse Monoclonal anti-FZD4 antibody has been validated for FACS. It is suitable to detect FZD4 in samples from Human.

Quick Overview for FZD4 antibody (PE) (ABIN2663398)

Target: FZD4 (Frizzled Family Receptor 4 (FZD4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FZD4 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: CH3A4A7

Product Details anti-FZD4 Antibody (PE)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for FZD4

Target: FZD4 (Frizzled Family Receptor 4 (FZD4))

Alternative Name: CD344

Background: CD344 is a member of the Frizzled family, known as Frizzled-4 (Fz4, FZD4, hFz4, or FzE4). Ten frizzled member have been identified in humans. Human FZD4 gene has been mapped to chromosome 11q14-q21. FZD4 is a 48-53 kD seven transmembrane G-protein-coupled receptor (GPCR), a receptor for Wnt proteins and norrie. It is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). FZD4 is a neuronal stem cell marker and is also expressed on fetal neuronal progenitor cells and neuronal intestinal cells. Kidney, lung, brain and liver express abundant of FZD4. It has been reported that FZD4 controls retinal and inner ear angiogenesis, participates in the regulation of embryonic development, tissue and cell polarization and proliferation.

Pathways: WNT Signaling, Hormone Transport, Sensory Perception of Sound