IL-4 antibody (PE)

Catalog No. ABIN2663794

The PE-conjugated Rat Monoclonal anti-IL-4 antibody (Clone MP4-25D2) (ABIN2663794) specifically detects IL-4 in FACS. The antibody is reactive with Human samples.

Quick Overview for IL-4 antibody (PE) (ABIN2663794)

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-4 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: MP4-25D2

Product Details anti-IL-4 Antibody (PE)

Cross-Reactivity: Pig (Porcine), Rhesus Monkey

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL-4

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Alternative Name: IL-4

Background: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naive CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation