LTBR antibody (PE)

Catalog No. ABIN2663837

The PE-conjugated Mouse Monoclonal anti-LTBR antibody (Clone 31G4D8) (ABIN2663837) specifically detects LTBR in FACS and IF. The antibody is reactive with Human samples.

Quick Overview for LTBR antibody (PE) (ABIN2663837)

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LTBR antibody is conjugated to PE

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 31G4D8

Product Details anti-LTBR Antibody (PE)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for LTBR

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Alternative Name: Lymphotoxin beta Receptor

Background: LT-βR, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT-βR is a receptor for the heterotrimeric lymphotoxin complex (composed of LTα and LTβ as well as LIGHT). LT-βR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-βR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-βR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-βR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs. The 31G4D8 antibody has been shown to be useful for flow cytometry, Western blot, immunoprepicitation and and ELISA (detection antibody). In addition, the 31G4D8 antibody is an agonistic antibody for the LT-βR capable of inducing apoptosis (with IFN-γ treatment).

Pathways: NF-kappaB Signaling