Raet1d antibody (PE)

Catalog No. ABIN2663873

The PE-conjugated Mouse Monoclonal anti-Raet1d antibody (Clone Charlotte d1-23) (ABIN2663873) specifically detects Raet1d in FACS. The antibody is reactive with Mouse samples.

Quick Overview for Raet1d antibody (PE) (ABIN2663873)

Target: Raet1d (Retinoic Acid Early Transcript delta (Raet1d))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Raet1d antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: Charlotte d1-23

Product Details anti-Raet1d Antibody (PE)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for Raet1d

Target: Raet1d (Retinoic Acid Early Transcript delta (Raet1d))

Alternative Name: RAE-1delta

Background: RAE-1δ is one of the five RAE-1 family, GPI-linked membrane protein consisting of alpha, beta, gamma, delta, and epsilon. They are strong homology within the family, related by 92 % -95 % sequence identity. They are distantly related to MHC class I proteins. RAE-1 proteins are abundantly expressed in fetal tissues, but not in normal adult tissue. They are constitutively expressed on some tumors and can be induced by retinoid acid. Its ligand NKG2D is found on NK cells, many transformed cell lines, and LPS-stimulated peritoneal macrophages. The interaction of NKG2D with RAE-1 transmits stimulatory signals to NK cells and other hematopoietic cells, leading to enhanced proliferation, cytokine secretion and target killing. They are involved in the regulation of innate and immune cytotoxic responses to tumors, pathogen-infected cells, and autoimmune diseases.