CXCR4 antibody

Catalog No. ABIN2664313

The Mouse Monoclonal anti-CXCR4 antibody is suitable to detect CXCR4 in samples from Human. It has been validated for BCA.

Quick Overview for CXCR4 antibody (ABIN2664313)

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCR4 antibody is un-conjugated

Application: Biochemical Assay (BCA)

Clone: 12G5

Product Details anti-CXCR4 Antibody

Cross-Reactivity: Chimpanzee, Baboon, Cynomolgus, Rhesus Monkey, Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops), Sooty mangabey (Cercocebus atys), Green Monkey (Chlorocebus sabaeus)

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and EDTA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CXCR4

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CD184

Background: CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2.

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events