IB-alpha antibody
This Mouse Monoclonal antibody specifically detects IB-alpha in FACS. It exhibits reactivity toward Human.
Catalog No. ABIN2665062
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Quick Overview for IB-alpha antibody (ABIN2665062)
Target
IB-alpha
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Application
Flow Cytometry (FACS)
Clone
3D6C02
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Cross-Reactivity
- Mouse (Murine)
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Cross-Reactivity (Details)
- Weakly reacts with mouse
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Purification
- The antibody was purified by affinity chromatography.
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Isotype
- IgG2b kappa
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 0.5 mg/mL
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Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- IB-alpha
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Background
- IκB-α is an inhibitory protein that binds to the NF-κB complex and retains this complex in the cytoplasm where it cannot activate transcription. Upon cellular stimulation, the IκB proteins are phosphorylated and degraded via the ubiquitin pathway allowing for nuclear translocation of NF-κB. The NF-κB complex can then bind DNA to activate gene expression of multiple proteins involved in inflammation, cellular proliferation, differentiation, and apoptosis.
Target
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