IL-31 antibody

Catalog No. ABIN2665157

The Rat Monoclonal anti-IL-31 antibody (Clone 1C2B07) (ABIN2665157) specifically detects IL-31 in BCA. The antibody is reactive with Mouse samples.

Quick Overview for IL-31 antibody (ABIN2665157)

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-31 antibody is un-conjugated

Application: Biochemical Assay (BCA)

Clone: 1C2B07

Product Details anti-IL-31 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL-31

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Alternative Name: IL-31

Background: IL-31, mainly produced by activated CD4+ T cells, is a helical cytokine belonging to the gp130/IL-6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Transgenic mice overexpressing IL-31 developed severe dermatitis, indicating that IL-31 is involved in skin immunity.