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IL-22 antibody (Ala34)

IL22 Reactivity: Human WB, IHC, FACS, Func Host: Goat Polyclonal Poly5161 unconjugated
Catalog No. ABIN2665496
  • Target See all IL-22 (IL22) Antibodies
    IL-22 (IL22) (Interleukin 22 (IL22))
    Binding Specificity
    • 16
    • 16
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Ala34
    Reactivity
    • 74
    • 40
    • 26
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 66
    • 12
    • 9
    • 4
    Goat
    Clonality
    • 69
    • 21
    • 1
    Polyclonal
    Conjugate
    • 48
    • 15
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-22 antibody is un-conjugated
    Application
    • 73
    • 47
    • 24
    • 13
    • 13
    • 11
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Functional Studies (Func)
    Cross-Reactivity (Details)
    In sandwich ELISA, less than 10 % cross-reactivity with recombinant mouse IL-22.
    Purification
    The antibody was purified by antigen affinity chromatography.
    Immunogen
    Ala34-Isoleucin179 (Accession# NM_020525) was expressed in E. coli.
    Clone
    Poly5161
    Isotype
    Ig Fraction, IgG
    Top Product
    Discover our top product IL22 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    IL-22 (IL22) (Interleukin 22 (IL22))
    Alternative Name
    IL-22 (IL22 Products)
    Synonyms
    IL-21 antibody, IL-22 antibody, IL-D110 antibody, IL-TIF antibody, ILTIF antibody, TIFIL-23 antibody, TIFa antibody, zcyto18 antibody, IL-22a antibody, ILTIFa antibody, Iltif antibody, RGD1561292 antibody, interleukin-22 antibody, interleukin 22 antibody, IL22 antibody, il22 antibody, Il22 antibody
    Background
    IL-22 is a cytokine structurally related to IL-10. Originally identified as a murine gene induced by IL-9 in T and mast cells, IL-22 was initially designated ILTIF (IL-10-related T cell-derived inducible factor). IL-22 belongs to a family of cytokines with limited homology to IL-10, namely IL-10, IL-19, IL-20, IL-24, IL-26, and the IFN-λs, IL-28A, IL-28B and IL-29. Human IL-22 shares 79 % amino acid identity with murine IL-22 and 25 % identity with human IL-10. IL-22 biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains. Activity is further regulated through interactions with the soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex belong to the class II CRF. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 is produced by Th17 cells and newly identified Th22 cells. It plays a critical role in mucosal immunity in addition to the deregulated inflammation observed in autoimmune diseases.
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