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Leucine Peptidase antibody

Reactivity: Mouse, Human FACS, IP, IHC Host: Mouse Monoclonal TW7-28G11 unconjugated
Catalog No. ABIN2666017
  • Target
    Leucine Peptidase
    Reactivity
    Mouse, Human
    Host
    Mouse
    Clonality
    Monoclonal
    Application
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC)
    Brand
    Ultra-LEAF™
    Purification
    The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
    Sterility
    0.2 μm filtered
    Endotoxin Level

    Endotoxin level is <0.01 EU/μg of the protein (<0.001 ng/μg of the protein) as determined by the LAL test.

    Clone
    TW7-28G11
    Isotype
    IgG2b kappa
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Preservative
    Azide free
    Handling Advice
    This Ultra-LEAF™ solution contains no preservative, handle under aseptic conditions
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    Leucine Peptidase
    Alternative Name
    LAP
    Background
    Transforming growth factor beta (TGF-β) is a cytokine that has critical functions in the immune response by regulating Treg and Th17 cell differentiation. TGF-β is first synthesized as pro-TGF-β which is then cleaved by furin proprotein convertase in the Golgi apparatus to produce a latent TGF-β complex. This complex consists of non-covalently associated dimers of the N-terminal region of pro-TGF-β (latency-associated peptide, LAP) and C-terminal region of pro-TGF-β (mature TGF-β). The latent-TGF-β has been found on the membrane of activated Treg cells, immature dendritic cells, megakaryocytes, and platelets.
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