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LAT antibody

This Mouse Monoclonal antibody specifically detects LAT in BCA. It exhibits reactivity toward Human.
Catalog No. ABIN2666079

Quick Overview for LAT antibody (ABIN2666079)

Target

See all LAT Antibodies
LAT (Linker For Activation of T Cells (LAT))

Reactivity

  • 120
  • 49
  • 33
  • 1
Human

Host

  • 115
  • 10
  • 2
  • 1
Mouse

Clonality

  • 115
  • 13
Monoclonal

Conjugate

  • 77
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This LAT antibody is un-conjugated

Application

  • 86
  • 48
  • 39
  • 39
  • 23
  • 22
  • 15
  • 12
  • 9
  • 4
  • 3
  • 1
  • 1
  • 1
Biochemical Assay (BCA)

Clone

LAT1111
  • No Cross-Reactivity

    Mouse (Murine)

    Purification

    The antibody was purified by affinity chromatography.

    Isotype

    IgG1
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Concentration

    0.5 mg/mL

    Buffer

    phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Upon receipt, store between 2°C and 8°C.
  • Target

    LAT (Linker For Activation of T Cells (LAT))

    Alternative Name

    LAT

    Background

    LAT (linker for activation of T-cells) is a 36 kD phospho-tyrosine adaptor protein containing SH2 domains and a CVRC motif. Two LAT isoforms have been reported with approximate molecular weights of 36 kD and 38 kD. LAT is localized to lipid rafts, and is also a potential type III transmembrane protein, thought to be expressed in the juxtanuclear intracellular compartment. LAT links TCR engagement to Ras-MAPK activation, Ca2+ flux, IL-2 expression and is required for T-cell development. LAT is phosphorylated when activated by TCR cross-linking, where it recruits signaling molecules. LAT activation can be prevented by polyunsaturated fatty acids. LAT is modified by ZAP-70 and Syk phosphorylation and can also be palmitoylated. LAT has been reported to be associated with Grb2, Gads, Grap, PLC-γ1, p85 subunit PI3K, ZAP-70, Syk, Itk, Vav, SLP-76, and cbl.

    Pathways

    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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