IRF9 antibody

Catalog No. ABIN2666230

The Mouse Monoclonal anti-IRF9 antibody is suitable to detect IRF9 in samples from Human. It has been validated for FACS.

Quick Overview for IRF9 antibody (ABIN2666230)

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IRF9 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 5A3A39

Product Details anti-IRF9 Antibody

Purification: Affinity purified.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted 2°C and 8°C.

Target Details for IRF9

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Alternative Name: IRF9

Background: IRF9 is a member of the IRF family of transcription factors and plays an important role in IFN signaling pathways and anti-viral immune responses. Type I and type III interferon stimulation induces phosphorylation and heterodimerization of STAT1 and STAT2. The activated STAT1:STAT2 heterodimer recruits IRF9 and forms a heterotrimeric complex termed IFN-stimulated gene factor 3 (ISGF3). The ISGF3 complex, in turn, translocates to the nucleus and transactivates IFN-inducible genes. The IRF9 protein in the ISGF3 complex is responsible for the recognition of IFN-stimulated response elements (ISRE). Mice lacking IRF9 fail to induce the expression of IFN regulated genes in response to type I interferon stimulation, indicating that IRF9 is crucial in mediating interferon signaling.

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Hepatitis C