c-Rel antibody

Catalog No. ABIN2666277

This Mouse Monoclonal antibody specifically detects c-Rel in FACS. It exhibits reactivity toward Human.

Quick Overview for c-Rel antibody (ABIN2666277)

Target: c-Rel (REL proto-oncogene (c-Rel))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This c-Rel antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 2F5A22

Product Details anti-c-Rel Antibody

Purification: Affinity purified

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for c-Rel

Target: c-Rel (REL proto-oncogene (c-Rel))

Alternative Name: C-REL

Background: C-Rel is a member of the Rel/NF-κB transcription factor family that forms homo or heterodimers with family members such as RelA/p65, RelB, NF- κB1/p105, and NF-κB2/p100. The NF-κB complex is retained in cytoplasm by the inhibitor IκB protein in unstimulated cells. Upon activation, IκB is degraded via the ubiquitin-proteasome pathway, which results in nuclear translocation of the active NF-κB complex. While other NF-κB transcription factors are expressed in most cell types, relatively higher levels of c-REL expression are found in hematopoietic cells. c-REL is thought to play key roles in regulating proliferation, differentiation, and survival of B and T lymphocytes.