ATIC antibody

Catalog No. ABIN2666312

The Mouse Monoclonal anti-ATIC antibody (Clone F38P7H9) (ABIN2666312) specifically detects ATIC in BCA. The antibody is reactive with Human, Mouse, Rat, Drosophila melanogaster and Frog samples.

Quick Overview for ATIC antibody (ABIN2666312)

Target: ATIC (5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))

Reactivity: Human, Mouse, Rat, Drosophila melanogaster, Frog

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATIC antibody is un-conjugated

Application: Biochemical Assay (BCA)

Clone: F38P7H9

Product Details anti-ATIC Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for ATIC

Target: ATIC (5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))

Alternative Name: ATIC

Background: ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP. AICA-ribosiduria is a recently discovered inherited metabolic disease caused by a defect in final steps of purine de novo biosynthesis. Clone F38P7H9 has been shown to be useful for western blotting and immunohistochemistry of human, mouse, rat, frog and fruit fly ATIC.