DDX58 antibody

Catalog No. ABIN2666363

The Rat Monoclonal anti-DDX58 antibody is suitable to detect DDX58 in samples from Mouse. It has been validated for FACS.

Quick Overview for DDX58 antibody (ABIN2666363)

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This DDX58 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: SS1A

Product Details anti-DDX58 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for DDX58

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Alternative Name: RIG-1

Background: RIG-1/DDX58(Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal forinnate antiviral responses including the production of typeI IFN. Clone SS1A has been shown to be useful for western blotting of the mouse RIG-1 protein.

Pathways: Activation of Innate immune Response, Hepatitis C