GPR177/WLS antibody

Catalog No. ABIN2666414

The Mouse Monoclonal anti-GPR177/WLS antibody (Clone YJ5) (ABIN2666414) specifically detects GPR177/WLS in FACS. The antibody is reactive with Human samples.

Quick Overview for GPR177/WLS antibody (ABIN2666414)

Target: GPR177/WLS (WLS) (Wntless Homolog (WLS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GPR177/WLS antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: YJ5

Product Details anti-GPR177/WLS Antibody

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for GPR177/WLS

Target: GPR177/WLS (WLS) (Wntless Homolog (WLS))

Alternative Name: Wntless

Background: Wnt signaling plays important roles in embryonic development and cancer formation. Wntless (GPR177) is a putative G-protein coupled receptor that regulates Wnt's trafficking and secretion. It can regulate the expression, subcellular location, binding, and organelle-specific association of Wnt proteins. In mammals, Wntless is mainly expressed in submucosa, muscle, ganglia, and nerve cells of the large intestines. Overexpression of Wntless may activate the NF-κB signaling pathway in cancer cells.

Pathways: WNT Signaling