SNAIL antibody

Catalog No. ABIN2668578

This Rat Monoclonal antibody specifically detects SNAIL in WB and IHC. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for SNAIL antibody (ABIN2668578)

Target: SNAIL (SNAI1)

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 9H2

Product Details anti-SNAIL Antibody

Purpose: SNAI1 / Snail antibody (mAb) (Clone 9H2)

Purification: Protein G Chromatography

Immunogen: This antibody was raised against a full-length recombinant protein corresponding to human SNAI1.

Isotype: IgG2a

Application Details

Application Notes: This antibody is also available as an AbFlex engineered recombinant antibody. For details on the corresponding AbFlex Recombinant Antibody, see Catalog No. 91255.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-SNAIL antibody (ABIN2668578)

Yanagawa, Walser, Zhu, Hong, Fishbein, Mah, Chia, Goodglick, Elashoff, Luo, Magyar, Dohadwala, Lee, St John, Strieter, Sharma, Dubinett: "Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 22, pp. 6820-9, (2009) (PubMed).

Rosivatz, Becker, Kremmer, Schott, Blechschmidt, Höfler, Sarbia: "Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract." in: Virchows Archiv : an international journal of pathology, Vol. 448, Issue 3, pp. 277-87, (2006) (PubMed).

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1 / Snail

Background: SNAI1 / Snail (snail homolog 1 (Drosophila)) is involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm (By similarity). Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.

Molecular Weight: 32 kDa

Gene ID: 6615

NCBI Accession: NP_005976

Pathways: Negative Regulation of intrinsic apoptotic Signaling