HDAC11 antibody (AA 238-251)

Catalog No. ABIN2668595

The Rabbit Polyclonal anti-HDAC11 antibody (ABIN2668595) specifically detects HDAC11 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for HDAC11 antibody (AA 238-251) (ABIN2668595)

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HDAC11 Antibody

Binding Specificity: AA 238-251

Purpose: HDAC11 antibody (pAb)

Purification: Affinity Purified

Immunogen: This HDAC11 antibody was raised against a peptide corresponding to amino acid residues 238-251 of human HDAC11.

Isotype: IgG

Application Details

Application Notes: WB: 1 - 3 μg/mL dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1 % Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: PBS containing 0.2 % gelatin and 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: 4 °C,-20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Store at 4°C for short term. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for HDAC11

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Alternative Name: HDAC11

Background: HDAC11 (Histone Deacetylase 11) is a member of the class IV mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-e-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the e-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11). In humans, expression of HDAC11 is limited to only a few organs, including brain, heart, muscle and kidney, suggesting an important role of HDAC11 in those tissues.

Molecular Weight: 36 kDa

Gene ID: 79885

NCBI Accession: NP_001129513