PBX1 antibody

Catalog No. ABIN2668628

Cited in 2+ publications. The Mouse Monoclonal anti-PBX1 antibody (Clone CT 41-1) (ABIN2668628) specifically detects PBX1 in WB, IHC and ChIP. The antibody is reactive with Human samples.

Quick Overview for PBX1 antibody (ABIN2668628)

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PBX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Clone: CT 41-1

Product Details anti-PBX1 Antibody

Purpose: PBX1b antibody (mAb) (Clone CT 41.1)

Purification: Protein G Chromatography

Immunogen: This PBX1b antibody was raised against a recombinant protein corresponding to amino acids 319 - 347 of human PBX1b.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-PBX1 antibody (ABIN2668628)

Park, Shih, Wang: "Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer." in: Cancer research, Vol. 68, Issue 21, pp. 8852-60, (2008) (PubMed).

Brendolan, Ferretti, Salsi, Moses, Quaggin, Blasi, Cleary, Selleri: "A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny." in: Development (Cambridge, England), Vol. 132, Issue 13, pp. 3113-26, (2005) (PubMed).

Target Details for PBX1

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Alternative Name: PBX1b

Background: PBX proteins are a family of TALE-class transcription factors that associate with a subset of Hox proteins, enhancing their DNA binding affinities and specificities. PBX proteins also heterodimerize with the Meis/Prep subfamily of to form trimeric complexes with Hox proteins at specific DNA sites. Amino acids 348-430 are absent in isoform PBX1b.

Molecular Weight: 40 kDa

Gene ID: 5087

NCBI Accession: NP_001191890