MEIS1/MEIS2/MEIS3 (AA 50-390) antibody

Catalog No. ABIN2668724

Cited in 3+ publications. The Mouse Monoclonal anti-MEIS1/MEIS2/MEIS3 antibody (Clone 9-2-7) (ABIN2668724) specifically detects MEIS1/MEIS2/MEIS3 in ICC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for MEIS1/MEIS2/MEIS3 (AA 50-390) antibody (ABIN2668724)

Target: MEIS1/MEIS2/MEIS3

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 9-2-7

Product Details

Binding Specificity: AA 50-390

Purpose: MEIS 1/2/3 antibody (mAb) (Clone 9.2.7)

Purification: Protein A Chromatography

Immunogen: This MEIS antibody was raised against a recombinant protein corresponding to amino acids amino acids 50-390 mouse MEIS1.

Isotype: IgG1

Application Details

Application Notes: ICC/IF: 0.5 μg/mL dilution This antibody is also available as an AbFlex engineered recombinant antibody. For details on the corresponding AbFlex Recombinant Antibody, see Catalog No. 91259.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References

Przepiorski, Vanichapol, Espiritu, Crunk, Parasky, McDaniels, Emlet, Salisbury, Happ, Vernetti, MacDonald, Kellum, Kleyman, Baty, Davidson, Hukriede: "Modeling oxidative injury response in human kidney organoids." in: Stem cell research & therapy, Vol. 13, Issue 1, pp. 76, (2022) (PubMed).

Hilliard, Yao, El-Dahr: "Mdm2 is required for maintenance of the nephrogenic niche." in: Developmental biology, Vol. 387, Issue 1, pp. 1-14, (2014) (PubMed).

Shim, Kim, Shin, Kim, Park: "Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon." in: Molecular and cellular biology, Vol. 27, Issue 5, pp. 1614-30, (2007) (PubMed).

Target Details

Target: MEIS1/MEIS2/MEIS3

Alternative Name: MEIS 1/2/3

Background: The MEIS family or proteins (Myeloid Ecotropic viral Integration Site homologues) encode proteins that function as cofactors for the Homeobox (HOX) proteins. Homeobox genes play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. MEIS and a functionally related protein Pbx belong to the TALE (Three Amino acid Loop Extension) homeodomain superfamily of proteins. The role of MEIS proteins in the regulation of transcription is as yet unclear.

Molecular Weight: 54-66 kDa

Gene ID: 4211

NCBI Accession: NP_034919