MTF2 antibody

Catalog No. ABIN2668833

This Mouse Monoclonal antibody specifically detects MTF2 in WB. It exhibits reactivity toward Human.It has been mentioned in 1 publication

Quick Overview for MTF2 antibody (ABIN2668833)

Target: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTF2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3A9

Product Details anti-MTF2 Antibody

Purpose: PCL2 antibody (mAb) (Clone 3A9)

Purification: Protein G Chromatography

Immunogen: This PCL2 antibody was raised against a recombinant protein corresponding to amino acids 103 - 327 of mouse PCL2.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-MTF2 antibody (ABIN2668833)

Li, Isono, Yamada, Endo, Endoh, Shinga, Mizutani-Koseki, Otte, Casanova, Kitamura, Kamijo, Sharif, Ohara, Toyada, Bernstein, Brockdorff, Koseki: "Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes." in: Molecular and cellular biology, Vol. 31, Issue 2, pp. 351-64, (2010) (PubMed).

Target Details for MTF2

Target: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Alternative Name: PCL2

Background: PCL2 (Polycomb-like 2, MTF2, M96) is a member of the Polycomb PRC2 protein complex and is important in cell fate decisions and may play a role in recruitment of PRC2 to target genes and histone methylation. PCL2 regulates gene expression patterns controlling self-renewal and commitment in embryonic stem cells and plays a critical role in ESC differentiation and self-renewal. PCL2 contains two PHD fingers.

Molecular Weight: 70 kDa

Gene ID: 17765

NCBI Accession: NP_038855

Pathways: Stem Cell Maintenance