PRDM1 antibody

Catalog No. ABIN2668849

There are 5+ publications for this product available. The Mouse Monoclonal anti-PRDM1 antibody is suitable to detect PRDM1 in samples from Human. It has been validated for WB, IHC and IP.

Quick Overview for PRDM1 antibody (ABIN2668849)

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRDM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: ROS195

Product Details anti-PRDM1 Antibody

Purpose: PRDM1 / BLIMP1 antibody (mAb) (Clone ROS195)

Purification: Protein G Chromatography

Immunogen: This PRDM1 / BLIMP1 antibody was raised against full-length recombinant human PRDM1 / BLIMP1 protein.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-PRDM1 antibody (ABIN2668849)

Nie, Gomez, Landgraf, Garcia, Liu, Tan, Chadburn, Tuschl, Knowles, Tam: "MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas." in: The American journal of pathology, Vol. 173, Issue 1, pp. 242-52, (2008) (PubMed).

Zhao, Liu, Zhang, Wang, Leboeuf, Zhang, Ma, Garcia, Song, Li, Shen, Chen, Janin, Chen: "PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor." in: Blood, Vol. 111, Issue 7, pp. 3867-71, (2008) (PubMed).

Liu, Leboeuf, Shi, Li, Wang, Shen, Garcia, Shen, Chen, Janin, Chen, Zhao: "Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma." in: Blood, Vol. 110, Issue 1, pp. 339-44, (2007) (PubMed).

Garcia, Roncador, García, Sánz, Maestre, Lucas, Montes-Moreno, Fernandez Victoria, Martinez-Torrecuadrara, Marafioti, Mason, Piris: "PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma." in: Haematologica, Vol. 91, Issue 4, pp. 467-74, (2006) (PubMed).

Valer Corellano: "[Malignant fibrous histiocytoma of soft tissues: early report of 10 cases]." in: Medicina clínica, Vol. 97, Issue 7, pp. 279, (1991) (PubMed).

Target Details for PRDM1

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Alternative Name: PRDM1 / BLIMP1

Background: PRDM1 / BLIMP1 is a transcriptional repressor that binds to specific target sites in DNA and recruits co-repressors. PRDM1 / BLIMP1 is a master regulator for B cell terminal differentiation, is essential for normal development and immunity and a putative tumor suppressor in diffuse large B cell lymphomas (DLBCLs). PRDM1 / BLIMP1 specifies primordial germ cells through the silencing of the default somatic pathway. PRDM1 / BLIMP1 also acts as a master regulator of intestinal maturation.

Molecular Weight: 77 & 95 kDa

Gene ID: 639

NCBI Accession: NP_001189

Pathways: Regulation of Muscle Cell Differentiation