MALT1 antibody (AA 701-808)

Catalog No. ABIN2668934

The Mouse Monoclonal anti-MALT1 antibody (ABIN2668934) specifically detects MALT1 in WB. The antibody is reactive with Human samples.

Quick Overview for MALT1 antibody (AA 701-808) (ABIN2668934)

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MALT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MALT1 Antibody

Binding Specificity: AA 701-808

Purpose: MALT1 antibody (mAb)

Purification: Protein G Chromatography

Immunogen: This MALT1 antibody was raised against a recombinant protein corresponding to amino acids 701-808 of mouse MALT1.

Isotype: IgG

Application Details

Application Notes: WB: 0.5 - 2 μg/mL dilution

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for MALT1

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Alternative Name: MALT1

Background: MALT1 enhances Bcl10-induced activation of NFkB and is also involved in nuclear export of Bcl10. MALT1 binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. MALT1-dependent Bcl10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. MALT1 was independently identified as a protein of 824 amino acids, and human MALT2 isoform b is an amino acid protein of 813 amino acids. MALT1 is thought to play a role in NFkB signaling by enhancing NFkB (NFkB p50 & NFkB p65) activation through interaction with Bcl10. Interaction between MALT1 and Bcl10 mediates IKK (IKKa, IKKb, IKKi/IKKe and IKKg) activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13.

Molecular Weight: 92 kDa

Gene ID: 10892

NCBI Accession: NP_006776

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins