STAT5 A/B antibody (pTyr694, pTyr699)

Catalog No. ABIN2668940

Cited in 1 publication. The Rabbit Polyclonal anti-STAT5 A/B antibody (ABIN2668940) specifically detects STAT5 A/B in WB and DB. The antibody is reactive with Human samples.

Quick Overview for STAT5 A/B antibody (pTyr694, pTyr699) (ABIN2668940)

Target: STAT5 A/B

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT5 A/B antibody is un-conjugated

Application: Western Blotting (WB), Dot Blot (DB)

Product Details anti-STAT5 A/B Antibody

Binding Specificity: pTyr694, pTyr699

Purpose: STAT5A/B phospho Tyr694/Tyr699 antibody (pAb)

Purification: Affinity Purified

Immunogen: This STAT5A/B phospho Tyr694/Tyr699 antibody was raised against a peptide containing phospho Tyr694 of human STAT5A. Human STAT5B shares the identical sequence surrounding Tyr699.

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2,000 dilution

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-STAT5 A/B antibody (ABIN2668940)

Basu, Wu, Kopchick: "Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways." in: Oncotarget, Vol. 8, Issue 13, pp. 21579-21598, (2017) (PubMed).

Target Details for STAT5 A/B

Target: STAT5 A/B

Alternative Name: STAT5A/B

Background: STAT5A/B (signal transducer and activator of transcription 5) is a member of the STAT family of transcription factors. STATs undergo serine and tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. The STAT5 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFNA1, IL-10, IL-6, IL-11, IL-12, IL-2, EGF, among others. Other members of the STAT family include STAT1a, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.

Molecular Weight: 92 kDa

Gene ID: 6776