beta-2 Microglobulin antibody

Catalog No. ABIN2688852

The Mouse Monoclonal anti-beta-2 Microglobulin antibody has been validated for FACS, IF and CyTox. It is suitable to detect beta-2 Microglobulin in samples from Mouse. There are 4+ publications available.

Quick Overview for beta-2 Microglobulin antibody (ABIN2688852)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Cytotoxicity Test (CyTox)

Clone: S19-8

Product Details anti-beta-2 Microglobulin Antibody

Brand: BD Pharmingen™

Characteristics: The s19.8 antibody reacts with the b and c alloantigens of β2 microglobulin, originally designated Ly-m11. β2 microglobulin is a 12 kDa protein, homologous to a single immunoglobulin constant-region domain, which is noncovalently associated with the MHC class I heavy chain. It may also associate noncovalently with CD1d in some cells types. Positive strains include C57BL/6, C57BL/10, C57BR, and C57L, whereas, A, AKR, BALB/c, C58, C3H, CBA, DBA/1, DBA/2, SJL, SWR, and 129 strains are negative.

BD Pharmingen™ Purified Mouse Anti-Mouse β2 Microglobulin[b,c] - Purified - Clone S19.8 - Isotype Mouse IgG2b, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: B10.S Mouse Spleen Cells

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-beta-2 Microglobulin antibody (ABIN2688852)

Pérarnau, Saron, Reina San Martin, Bervas, Ong, Soloski, Smith, Ure, Gairin, Lemonnier: "Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses." in: European journal of immunology, Vol. 29, Issue 4, pp. 1243-52, (1999) (PubMed).

Jullien, Brossay, Sieling, Modlin, Kronenberg: "CD1: clues on a new antigen-presenting pathway." in: Research in immunology, Vol. 147, Issue 5, pp. 321-8, (1997) (PubMed).

Tada, Kimura, Hatzfeld, Hämmerling: "Ly-m11: the H-3 region of mouse chromosome 2 controls a new surface alloantigen." in: Immunogenetics, Vol. 11, Issue 5, pp. 441-9, (1991) (PubMed).

Kurtz, Graff, Adelman, Martin-Morgan, Click: "CTL and serologically defined antigens of B2m,H-3 region." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 135, Issue 4, pp. 2847-52, (1985) (PubMed).

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: Beta2-Microglobulin

Background: Synonyms: Ly-m11

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process