TNFSF8 antibody

Catalog No. ABIN2688991

Cited in 3+ publications. The Mouse Monoclonal anti-TNFSF8 antibody (Clone D2) (ABIN2688991) specifically detects TNFSF8 in FACS. The antibody is reactive with Human samples.

Quick Overview for TNFSF8 antibody (ABIN2688991)

Target: TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFSF8 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: D2

Product Details anti-TNFSF8 Antibody

Characteristics: Reacts with CD30 ligand (CD153) a 40 kDa type II membrane glycoprotein expressed mainly on activated T cells, as well as on activated macrophages, neutrophils and both normal and malignant B cells. CD30 ligand is a member of the tumor necrosis factor (TNF) superfamily. In addition to TNF, this family also includes lymphotoxin α (LTα), LTβ, CD154, CD95L, CD70, CD134 ligand, CDw137 ligand, and TRAIL. Results of in vitro studies have shown that CD30 mediates a variety of activation and differentiation, or apoptotic signals. Recently, it has been reported that CD30-deficient mice have elevated numbers of thymocytes and show a gross defect in negative but not positive selection during T cell differentiation, suggesting an important role for CD30/CD30L interactions in the deletion of autoreactive T cells. Profile of PMA & CA++ ionophore- stimulated peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD153 - Purified - Clone D2-1173 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-TNFSF8 antibody (ABIN2688991)

Romagnani, Annunziato, Manetti, Mavilia, Lasagni, Manuelli, Vannelli, Vanini, Maggi, Pupilli, Romagnani: "High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymus." in: Blood, Vol. 91, Issue 9, pp. 3323-32, (1998) (PubMed).

Del Prete, De Carli, DElios, Daniel, Almerigogna, Alderson, Smith, Thomas, Romagnani: "CD30-mediated signaling promotes the development of human T helper type 2-like T cells." in: The Journal of experimental medicine, Vol. 182, Issue 6, pp. 1655-61, (1996) (PubMed).

Smith, Gruss, Davis, Anderson, Farrah, Baker, Sutherland, Brannan, Copeland, Jenkins: "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF." in: Cell, Vol. 73, Issue 7, pp. 1349-60, (1993) (PubMed).

Target Details for TNFSF8

Target: TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))

Alternative Name: CD153

Background: Synonyms: CD30L