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CD1d antibody

CD1D Reactivity: Mouse FACS, IP, IF, IHC (fro), BR Host: Rat Monoclonal 3C11 unconjugated
Catalog No. ABIN2689067
  • Target See all CD1d (CD1D) Antibodies
    CD1d (CD1D) (CD1d Molecule (CD1D))
    Reactivity
    • 57
    • 34
    • 16
    • 4
    Mouse
    Host
    • 59
    • 15
    • 11
    Rat
    Clonality
    • 61
    • 24
    Monoclonal
    Conjugate
    • 37
    • 8
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD1d antibody is un-conjugated
    Application
    • 41
    • 35
    • 21
    • 11
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)
    Brand
    BD Pharmingen™
    Characteristics
    The 3C11 antibody reacts with CD1d, a 48- kDa glycoprotein with structural homology to the major histocompatibility complex (MHC) class I molecules. The structure, expression, and functions of CD1 antigens are complex and have been reviewed. mAb 3C11 detects CD1d at varying levels on most types of bone marrow and peripheral leukocytes and on epithelial, dendritic, and lymphoid cells in the thymus. It appears to recognize CD1d only in association with β2m. CD1d has been reported to be expressed by gastrointestinal tract epithelium and in the cytoplasm of hepatocytes as detected via immunohistochemical staining of frozen sections with mAb 3C11, suggesting a possible role for CD1d in mucosal immunity. However, CD1d expression was not detectable, via flow cytometry, on intestinal epithelial cells in studies using the anti-CD1d mAbs 3C11, 1B1 (Cat. no. 553843, for the purified antibody), and 9C7. The 3C11 mAb is reported to cross-react with human CD1d, and it competes with mAb 1B1 (Cat. no. 553844) in binding to mouse splenocytes.

    BD Pharmingen™ Purified Rat Anti-Mouse CD1d - Purified - Clone 3C11 - Isotype Rat IgM, κ - Reactivity Ms - 0.5 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    L cells (derived from C3H/An mouse) expressing full-length mouse Cd1.1 cDNA
    Clone
    3C11
    Isotype
    IgM kappa
    Top Product
    Discover our top product CD1D Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Porcelli, Modlin: "The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids." in: Annual review of immunology, Vol. 17, pp. 297-329, (1999) (PubMed).

    Amano, Baumgarth, Dick, Brossay, Kronenberg, Herzenberg, Strober: "CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 4, pp. 1710-7, (1998) (PubMed).

    Roark, Park, Jayawardena, Kavita, Shannon, Bendelac: "CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3121-7, (1998) (PubMed).

    Sydora, Brossay, Hagenbaugh, Kronenberg, Cheroutre: "TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4209-16, (1996) (PubMed).

    Balk, Burke, Polischuk, Frantz, Yang, Porcelli, Colgan, Blumberg: "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium." in: Science (New York, N.Y.), Vol. 265, Issue 5169, pp. 259-62, (1994) (PubMed).

    Bleicher, Balk, Hagen, Blumberg, Flotte, Terhorst: "Expression of murine CD1 on gastrointestinal epithelium." in: Science (New York, N.Y.), Vol. 250, Issue 4981, pp. 679-82, (1990) (PubMed).

  • Target
    CD1d (CD1D) (CD1d Molecule (CD1D))
    Alternative Name
    CD1d (CD1D Products)
    Synonyms
    CD1A antibody, R3 antibody, CD1D antibody, CD1D1 antibody, CD1d molecule antibody, CD1D antigen, d polypeptide antibody, CD1D antibody
    Background
    Synonyms: CD1.1, Ly-38
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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