PROCR antibody

Catalog No. ABIN2689080

There are 2+ publications for this product available. The Rat Monoclonal anti-PROCR antibody is suitable to detect PROCR in samples from Human. It has been validated for FACS.

Quick Overview for PROCR antibody (ABIN2689080)

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This PROCR antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: RCR

Product Details anti-PROCR Antibody

Characteristics: Reacts with endothelial cell protein C receptor (EPCR), a 25 kDa, type I transmembrane glycoprotein, expressed on endothelial cells in arteries, veins and capillaries. EPCR is also referred to as CD201. It binds protein C and augments its activation. Reports indicate that EPCR is expressed on several malignant cell lines. Malignant cell lines that express EPCR also show significant levels of protein C activation and this activation could be inhibited by anti-EPCR antibody. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of anti-CD201 (RCR-252) reactivity on ECV304 cells analyzed by flow cytometry. Second step staining with Cat. No. 554016.

BD Pharmingen™ Purified Rat Anti-Human CD201 - Purified - Clone RCR-252 - Isotype Rat IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-PROCR antibody (ABIN2689080)

Biguzzi, Merati, Liaw, Bucciarelli, Oganesyan, Qu, Gu, Fetiveau, Esmon, Mannucci, Faioni: "A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function." in: Thrombosis and haemostasis, Vol. 86, Issue 4, pp. 945-8, (2001) (PubMed).

Tsuneyoshi, Fukudome, Horiguchi, Ye, Matsuzaki, Toi, Suzuki, Kimoto: "Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines." in: Thrombosis and haemostasis, Vol. 85, Issue 2, pp. 356-61, (2001) (PubMed).

Target Details for PROCR

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Alternative Name: CD201

Background: Synonyms: EPCR