IL12RB1 antibody

Catalog No. ABIN2689091

This Mouse Monoclonal antibody specifically detects IL12RB1 in FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for IL12RB1 antibody (ABIN2689091)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 2-4E6

Product Details anti-IL12RB1 Antibody

Characteristics: Reacts with IL-12Rβ1 subunit, one of two subunits of the IL-12Rβ. IL-12R, expressed mainly on T cells or NK cells, is a member of the hemopoietin receptor superfamily and is related to gp130, granulocyte-colony stimulating factor (G-CSF) receptor and leukemia inhibitory factor (LIF). Reports indicate that together, subunits IL-12Rβ1 and IL-12Rβ2 bind IL-12 with high affinity. IL-12 is an immunomodulatory cytokine produced mainly by antigen-presenting cells (APC) and plays a role in promoting Th1-type responses and cell-mediated immunity. It stimulates proliferation of T cells and NK cells, enhances lytic activity of lymphokine-activated killer (LAK) cells and CTL. Profile of IL-12Rβ1 expressed on peripheral blood lymphocytes analyzed on a FACScan .

BD Pharmingen™ Purified Mouse Anti-Human CD212 - Purified - Clone 2.4E6 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-IL12RB1 antibody (ABIN2689091)

Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).

Wu, Warrier, Carvajal, Chua, Minetti, Chizzonite, Mongini, Stern, Gubler, Presky, Gately: "Biological function and distribution of human interleukin-12 receptor beta chain." in: European journal of immunology, Vol. 26, Issue 2, pp. 345-50, (1996) (PubMed).

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Alternative Name: CD212

Background: Synonyms: IL-12 receptor β1 subunit

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation